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Statistical testing against baseline was common in dental research.
Despina Koletsi1, Arun Madahar2, Padhraig S Fleming2
1Department of Orthodontics, School of Dentistry, University of Athens, 2 Thivon St, 11527 Goudi, Athens, Greece.
Many dental studies use baseline comparisons, but their interpretation needs improvement. Enhanced statistical reporting is crucial for accurate research findings in dentistry.
Area of Science:
- Dental research methodology
- Biostatistics in clinical studies
Background:
- Within-group comparisons to baseline are frequently employed in dental research.
- The appropriate conduct and interpretation of these statistical analyses are critical for valid research outcomes.
Purpose of the Study:
- To evaluate the prevalence of within-group comparisons with baseline in leading dental journals.
- To investigate associations between the use of baseline comparisons and study characteristics like journal and design.
Main Methods:
- Electronic search of 30 consecutive issues from five prominent dental journals.
- Assessment of statistical analysis conduct, reporting, and interpretation, focusing on baseline comparisons.
- Descriptive statistics and chi-square/Fisher's exact tests to analyze associations.
Main Results:
- 184 studies were analyzed; 43 (23%) used baseline comparisons for outcome interpretation.
- The Journal of Endodontics published the highest proportion of studies (46%).
- Inappropriate baseline testing was less frequent in interventional studies (P < 0.001).
Conclusions:
- Comparisons with baseline are common in both observational and interventional dental research.
- Improved statistical conduct and reporting are necessary for appropriate and informative research inferences.
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