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An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia

Shuihong Wang1, Houquan Lu2, Jianliang Ni1

  • 1Tongde Hospital of Zhejiang Province, Zhejiang, China.

Neuroscience Letters
|February 10, 2015
PubMed

Insights

Genetic variants in C4BPB and C4BPA genes were not associated with schizophrenia risk in a Han Chinese population. This study suggests these complement genes may not play a direct role in schizophrenia susceptibility.

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Maternal infections during pregnancy are linked to increased schizophrenia risk in offspring.
  • Reduced levels of C4b-binding protein (C4BP), a complement inhibitor, have been previously associated with schizophrenia.
  • The genetic basis for the link between infections, C4BP, and schizophrenia remains unclear.

Purpose of the Study:

  • To investigate whether common variants in C4BPB and C4BPA genes confer susceptibility to schizophrenia.
  • To explore the potential role of C4BP gene variants in the observed association between C4BP levels and schizophrenia risk.

Main Methods:

  • Case-control study design involving 556 schizophrenia patients and 610 healthy controls.
  • Analysis of 4 single nucleotide polymorphisms (SNPs) in C4BPB and 5 SNPs in C4BPA.
  • Comparison of genotype and allele frequencies of selected SNPs between patient and control groups.

Main Results:

  • No statistically significant association was found between the analyzed C4BPB/C4BPA variants and schizophrenia.
  • Genotype and allele frequencies of the studied SNPs did not differ between schizophrenia cases and healthy controls.

Conclusions:

  • The findings suggest that common C4BPB and C4BPA gene variants do not confer susceptibility to schizophrenia in the studied Han Chinese population.
  • Further large-scale genetic studies are needed to confirm these preliminary results and fully elucidate the role of complement system genes in schizophrenia.

Keywords:
C4b-binding proteinPolymorphismSchizophrenia

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