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Catalpol regulates cholinergic nerve system function through effect on choline acetyl-transferase not M receptor

Jin-Hong Wang1, Hai Xie2, Ting-Kun Zhao1

  • 1Key Laboratory of Applied Pharmacology of Shandong Province, Weifang Medical University, Weifang, Shandong 261053, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 10, 2015
PubMed
Summary

Catalpol treatment increased choline acetyl-transferase (ChAT) levels in Alzheimer's disease (AD) models, suggesting a potential therapeutic benefit for AD by regulating the cholinergic system. However, it did not affect muscarinic receptor affinity.

Keywords:
Aβ(25–35)CatalpolCholine acetyl-transferase (ChAT)Cholinergic nerve systemM receptor affinity

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