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Published on: August 13, 2019
GYY4137 promotes bone formation in a rabbit distraction osteogenesis model: a preliminary report
Xiaowen Jiang1, Yanzhe Chen2, Kun Lu2
1Associate Professor, Department of Stomatology, First People's Hospital of Chenzhou and Institute of Translation Medicine, University of South China, Chenzhou, Hunan, China.
Purpose:
Hydrogen sulfide (H2S) has been shown to enhance bone formation, but its osteogenic effect is unclarified during distraction osteogenesis (DO). This study tested the hypothesis that H2S could promote bone formation in a rabbit mandibular DO model.
Materials And Methods:
Unilateral mandibular lengthening was achieved in 26 rabbits. During the distraction and the first week of consolidation, saline 0.2 mL or saline 0.2 mL and GYY4137 (H2S donor, 50 mg/kg) was injected intravenously twice a day. Distracted mandibles were examined by dual-energy x-ray absorptiometry, histology, computed tomography, and a 3-point bending test 8 weeks after distraction.
Results:
The GYY4137-treated animals presented a greater response as measured by bone mineral density and mechanical properties and a more mature microstructure of the lengthened mandibles compared with the saline-treated control animals.
Conclusion:
The results of this study suggest that H2S can accelerate osteogenesis during DO.
