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Prevalence and severity of depression in chronic viral hepatitis in Iran

Mojgan Mirabdolhagh Hazaveh1, Taraneh Dormohammadi Toosi2, Mohsen Nasiri Toosi3

  • 1Rheumatology Research Centre, Vali-asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Gastroenterology Report
|February 10, 2015
PubMed

Insights

Chronic hepatitis C patients show higher depression rates than healthy individuals and chronic hepatitis B patients. Depression screening is recommended for managing both hepatitis B and C.

Area of Science:

  • Hepatology and Gastroenterology
  • Psychiatry and Mental Health

Background:

  • Chronic hepatitis B (CHB) and chronic hepatitis C (CHC) are significant global health concerns.
  • Mental health comorbidities, such as depression, are increasingly recognized in patients with chronic liver diseases.
  • Understanding the prevalence and severity of depression in these patient groups is crucial for comprehensive care.

Purpose of the Study:

  • To compare the prevalence and severity of depression among patients with CHB, CHC, and healthy controls.
  • To investigate the impact of hepatitis B surface antigen (HBsAg) carrier status on depression rates in CHB patients.

Main Methods:

  • A cross-sectional study involving 253 participants was conducted between 2011 and 2012.
  • Depression prevalence and severity were assessed using the Hamilton Depression Rating Scale.
  • Participants included CHB patients, CHC patients, and healthy individuals.

Main Results:

  • The prevalence of depression was significantly higher in CHC patients (35.9%) compared to healthy participants (11.3%) and CHB patients (19.8%) (P < 0.01).
  • After excluding inactive HBsAg carriers, the difference in depression prevalence between CHB and CHC patients was not significant (29.3% vs. 35.9%).
  • Inactive HBsAg carriers exhibited a significantly lower depression prevalence (10.0%) compared to CHB patients excluding inactive carriers (29.3%) (P < 0.05).
  • No significant differences in depression severity were observed across all groups.

Conclusions:

  • Depression is more prevalent in CHC patients than in CHB patients and healthy individuals.
  • The presence of inactive HBsAg carriage may be associated with lower depression rates in CHB patients.
  • Routine depression screening is advisable for patients with CHB and CHC to aid in disease management.
Abstract

Keywords:
chronic hepatitisdepressionhepatitis Bhepatitis C

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