Synthesis of two β-cyclodextrin derivatives containing a vinyl group
Yong-Fu Li1, Yi-Ming Ha1, Qin Guo1
1The Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, Beijing 100193, China.
Abstract:
β-CD maleate (CDM) and β-CD itaconate (CDI) were prepared by esterification of β-cyclodextrin (β-CD) with maleic acid and itaconic acid using phosphate as a catalyst in a semi-dry process. The esterification of β-CD was carried out using [Itaconic acid ] or [Maleic acid ] 4 mol/mol of CD; M/L ratio 1:0.6; temperature 110 °C; [4-methoxyphenol] 2.5% amount of acid; reaction time 3.5h. The esterification rates of CDM and CDI are 70.38% and 21.02%, respectively. We found that CDM and CDI were both monoesters. Here, we also established a new evaluation method for the rate of esterification.
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