Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A combined therapeutic approach: extracorporeal shock wave therapy and botulinum toxin in multiple sclerosis-related spasticity.

Frontiers in neurology·2026
Same author

Botulinum toxin treatment for multiple sclerosis and post-stroke spasticity in clinical practice: differences in injection doses and patterns.

Frontiers in rehabilitation sciences·2026
Same author

Diagnosis and management of frontotemporal dementia: a narrative review.

Neurodegenerative disease management·2026
Same author

Effects of Focal Low-Energy Extracorporeal Shock Wave Treatment (ESWT) as an Add-On to Botulinum Toxin (BoNT) Injection on Pisa Syndrome in Parkinson's Disease.

Tremor and other hyperkinetic movements (New York, N.Y.)·2026
Same author

Risk factors for disease generalization in acetylcholine receptor antibody-positive ocular myasthenia: a multicenter retrospective study.

Frontiers in neurology·2026
Same author

Early bilingualism as a protective factor against acute post-stroke aphasia.

Journal of neurology·2026

Related Experiment Video

Updated: Apr 17, 2026

Cortical Source Analysis of High-Density EEG Recordings in Children
09:32

Cortical Source Analysis of High-Density EEG Recordings in Children

Published on: June 30, 2014

22.1K

Sleep affects cortical source modularity in temporal lobe epilepsy: A high-density EEG study.

Alessandra Del Felice1, Silvia Francesca Storti2, Paolo Manganotti3

  • 1Department of Neuroscience - SNPSRR, University of Padua, Padua, Italy.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|February 11, 2015
PubMed
Summary
This summary is machine-generated.

During sleep, interictal epileptiform discharges (IEDs) show a larger scalp projection and decreased cortical interaction in epilepsy patients. This suggests sleep alters IEDs by modifying brain network activity.

Keywords:
Brain oscillatory rhythmsElectrical source imaging (ESI)Epileptogenic zoneInterictal epileptiform discharge (IED)Perturbational approach

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.7K
Investigating Social Cognition in Infants and Adults Using Dense Array Electroencephalography dEEG
12:48

Investigating Social Cognition in Infants and Adults Using Dense Array Electroencephalography dEEG

Published on: June 27, 2011

18.4K

Related Experiment Videos

Last Updated: Apr 17, 2026

Cortical Source Analysis of High-Density EEG Recordings in Children
09:32

Cortical Source Analysis of High-Density EEG Recordings in Children

Published on: June 30, 2014

22.1K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.7K
Investigating Social Cognition in Infants and Adults Using Dense Array Electroencephalography dEEG
12:48

Investigating Social Cognition in Infants and Adults Using Dense Array Electroencephalography dEEG

Published on: June 27, 2011

18.4K

Area of Science:

  • Neuroscience
  • Epilepsy Research
  • Sleep Medicine

Background:

  • Interictal epileptiform discharges (IEDs) are brain rhythm perturbations, often more prominent during sleep.
  • Understanding how sleep state affects IEDs is crucial for epilepsy diagnosis and management.

Purpose of the Study:

  • To investigate if sleep influences the scalp spread of IEDs.
  • To determine if vigilance-related changes in cortical interactions affect IED distribution.

Main Methods:

  • Recorded 256-channel EEG during wake and sleep in 12 right temporal lobe epilepsy (TLE) patients (mesial vs. neocortical).
  • Compared scalp projection of IEDs between wake and sleep using t-tests.
  • Utilized low-resolution brain electromagnetic tomography (LORETA) to calculate cortical generators of IEDs.

Main Results:

  • A mean of 21 IEDs/wake and 39 IEDs/sleep per subject were identified.
  • IED scalp projection was significantly larger during sleep than wake in both mesial and neocortical TLE (p<0.05).
  • Cortical source analysis revealed alternating activations during wake, shifting to isolated/stationary activations (mesial TLE) or silencing (neocortical TLE) during sleep.

Conclusions:

  • Sleep increases the scalp region of IEDs and decreases cortical interaction in TLE.
  • Sleep- and wake-related cortical network interactions may influence IED appearance on scalp EEG.
  • IEDs may serve as indicators of cerebral oscillation perturbations.