Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Human Virome

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...

Vaccine Production

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to: Antimicrobial-coated sutures to decrease surgical site infections: a systematic review and meta-analysis.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2018

Same author

Fluoroscopy-guided removal of individualised airway-covered stents for airway fistulas.

Clinical radiology·2018

Same author

Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.

Osteoarthritis and cartilage·2018

Same author

The FBXW7 tumor suppressor inhibits breast cancer proliferation and promotes apoptosis by targeting MTDH for degradation.

Neoplasma·2018

Same author

Inhibition of ZERO-BK by PKC is involved in carbachol-induced enhancement of rat colon smooth muscle motility.

Neurogastroenterology and motility·2018

Same author

Gene expression profiling reveals candidate genes related to residual feed intake in duodenum of laying ducks.

Journal of animal science·2018

Search research articles

Related Experiment Video

Updated: Apr 17, 2026

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Recent vaccine development for human metapneumovirus.

J Ren¹, T Phan¹, X Bao²

¹1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.

The Journal of General Virology

|February 11, 2015

Summary

Human metapneumovirus (hMPV) causes significant respiratory illness in children and vulnerable adults. This review explores current hMPV vaccine development, highlighting the need for effective prevention strategies.

More Related Videos

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Related Experiment Videos

Last Updated: Apr 17, 2026

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Influenza A Virus Studies in a Mouse Model of Infection

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Area of Science:

Virology
Immunology
Vaccinology

Background:

Human metapneumovirus (hMPV) and respiratory syncytial virus are leading causes of lower respiratory tract infections in children.
hMPV also contributes to significant morbidity and mortality in immunocompromised individuals and the elderly.
Recurrent hMPV infections impose a substantial global health burden, necessitating preventative measures.

Purpose of the Study:

To review the current landscape of human metapneumovirus (hMPV) vaccine development.
To identify key areas for advancing hMPV-specific prophylactic treatments.
To emphasize the importance of understanding viral protein functions in host responses for vaccine design.

Main Methods:

Literature review of existing research on hMPV vaccine development.
Analysis of current challenges and progress in the field.
Synthesis of findings to propose future research directions.

Main Results:

There are currently no specific preventative treatments available for hMPV.
Vaccine development is ongoing, with various strategies being explored.
Understanding viral protein roles in host immunity is crucial for effective vaccine design.

Conclusions:

Effective vaccines against hMPV are urgently needed.
Further research into viral protein functions will be key to developing successful prophylactic vaccines.
Targeting host responses to viral proteins may offer a promising avenue for hMPV prevention.