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Intracellular delivery system for antibody-Peptide drug conjugates

Geoffrey Y Berguig1, Anthony J Convertine2, Shani Frayo3

  • 1Department of Bioengineering, University of Washington, Seattle, Washington, USA; Current address: BioMarin Pharmaceutical, Novato, California, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|February 12, 2015
PubMed
Summary

Researchers developed a novel polymeric micelle delivery system for enhanced cytosolic delivery of protein drugs, expanding antibody-drug conjugate therapy potential for cancer treatment. This system successfully suppressed tumor growth and prolonged survival in a lymphoma mouse model.

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