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Ring Opening Functionalization of Thiolactone Homopolymers for ROS Scavenging.

Aaron Priester1, Forrest Kievit2, Anthony J Convertine1

  • 1Missouri University of Science and Technology, Rolla, MO 65409, United States of America.

Journal of Polymer Science (2020)
|November 3, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed thiolactone acrylamide (TLA) polymers to neutralize reactive oxygen species (ROS) after traumatic brain injury (TBI). These TLA polymers offer tunable rapid and sustained ROS neutralization for TBI treatment.

Keywords:
RAFTROSTBIkineticstherapeuticthioetherthiol

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Neuroscience

Background:

  • Traumatic brain injury (TBI) leads to harmful reactive oxygen species (ROS).
  • Developing effective treatments for TBI-induced oxidative stress is crucial.
  • Polymers offer potential for targeted ROS scavenging.

Purpose of the Study:

  • To synthesize and characterize thiolactone acrylamide (TLA) polymers for ROS neutralization.
  • To investigate the modification of TLA polymers for tunable antioxidant properties.
  • To evaluate the efficacy of modified TLA polymers in neutralizing ROS relevant to TBI.

Main Methods:

  • Synthesis of TLA polymers via reversible addition-fragmentation chain transfer (RAFT) polymerization.
  • Modification of TLA polymers through ring-opening and thiol-ene reactions.
  • Characterization of polymer properties, including molar mass and dispersity.
  • Assessment of ROS neutralization capacity of modified polymers.

Main Results:

  • Well-defined TLA polymers with controlled molar masses were synthesized using RAFT polymerization.
  • Polymer modification yielded copolymers with varying thiol and thioether ratios.
  • Polymers with higher thiol content showed rapid ROS neutralization.
  • Thioether residues provided sustained ROS neutralization activity.

Conclusions:

  • TLA polymers can be synthesized with controlled characteristics for biomedical applications.
  • Post-polymerization modification allows for tuning of ROS scavenging kinetics.
  • These functionalized polymers show promise as therapeutic agents for TBI by neutralizing ROS.