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Updated: Jun 13, 2025

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
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Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery.

Ziwen Zhang1, Haotian Sun1, Justin Giannino2

  • 1Department of Chemical and Biological Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.

Journal of Polymer Science (2020)
|September 9, 2024
PubMed
Summary
This summary is machine-generated.

Biodegradable zwitterionic polymers (ZPs) offer a promising alternative to poly(ethylene glycol) (PEG) due to their biocompatibility and reduced immunogenicity. These advanced materials show potential for improved drug delivery systems without long-term side effects.

Keywords:
PEG alternativebiodegradable polymerdrug deliveryprotein deliveryzwitterionic polymer

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Poly(ethylene glycol) (PEG) is widely used in biomedicine but suffers from immunogenicity, limiting therapeutic efficacy.
  • Pegylated therapeutics can elicit immune responses, restricting their clinical applications.
  • There is a need for biocompatible polymers with reduced immunogenicity for advanced biomedical applications.

Purpose of the Study:

  • To provide a comprehensive review of biodegradable zwitterionic polymers (ZPs) as alternatives to PEG.
  • To discuss the structural designs and synthesis strategies of biodegradable ZPs.
  • To highlight the applications of biodegradable ZPs in drug delivery.

Main Methods:

  • Systematic review of recent scientific literature on biodegradable ZPs.
  • Analysis of structural designs and synthetic approaches for integrating biodegradable polymers with zwitterions.
  • Evaluation of ZP applications in delivering small molecule drugs and proteins.

Main Results:

  • Biodegradable ZPs exhibit excellent water solubility and immunological inertness.
  • These polymers offer favorable biomedical properties without significant long-term side effects.
  • Various structural designs and synthetic methods for biodegradable ZPs have been developed.

Conclusions:

  • Biodegradable ZPs represent a significant advancement over traditional PEG-based materials.
  • Their tunable properties and biocompatibility make them ideal for diverse drug delivery applications.
  • Further research into biodegradable ZPs promises enhanced therapeutic outcomes and reduced adverse effects.