Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polymer Capsules with Volatile Organic Compounds as Reference Materials for Controlled Emission.

ACS applied materials & interfaces·2024
Same author

Super-Resolved Protein Imaging Using Bifunctional Light-Up Aptamers.

Angewandte Chemie (International ed. in English)·2024
Same author

Stimulated emission double depletion nanoscopy with background correction at the single-pixel level.

Optics letters·2023
Same author

Fast-exchanging spirocyclic rhodamine probes for aptamer-based super-resolution RNA imaging.

Nature communications·2023
Same author

<i>In-vivo</i> time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats.

Frontiers in neurology·2023
Same author

Simultaneous structures in sign languages: Acquisition and emergence.

Frontiers in psychology·2023

Related Experiment Video

Updated: Apr 17, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.9K

Functionalized polystyrene nanoparticles as a platform for studying bio-nano interactions.

Cornelia Loos1, Tatiana Syrovets1, Anna Musyanovych2

  • 1Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, Helmholtzstr. 20, D-89081 Ulm, Germany.

Beilstein Journal of Nanotechnology
|February 12, 2015
PubMed
Summary

Polystyrene nanoparticles offer a versatile model for studying bio-nano interactions. Their surface chemistry influences biological behavior, making them valuable for understanding nanoparticle safety and applications.

Keywords:
amino groupsapoptosiscarboxyl groupscell proliferationleukemia cell linesmTORmacrophagespolystyrene nanoparticles

More Related Videos

Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

8.2K
Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

3.1K

Related Experiment Videos

Last Updated: Apr 17, 2026

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

10.9K
Nanosponge Tunability in Size and Crosslinking Density
11:15

Nanosponge Tunability in Size and Crosslinking Density

Published on: August 4, 2017

8.2K
Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

3.1K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Nanoparticles have diverse applications but their biological interactions and hazards are poorly understood.
  • Nanoparticle properties, especially surface chemistry, critically affect biological interactions, solubility, and distribution.
  • Polystyrene nanoparticles are ideal models due to tunable size, surface functionalization, and lack of degradation/cytotoxicity.

Purpose of the Study:

  • To review and compare studies on polystyrene nanoparticles with superparamagnetic iron oxide nanoparticles.
  • To highlight the role of surface characteristics in bio-nano interactions using polystyrene nanoparticles as a model.
  • To investigate the biological impact and hazards of nanoparticles.

Main Methods:

  • Review of existing literature on polystyrene nanoparticles (PS-NPs) and superparamagnetic iron oxide nanoparticles (SPIONs).
  • Analysis of studies focusing on surface chemistry, charge, size, and functionalization of PS-NPs.
  • Comparison of PS-NPs with SPIONs regarding biocompatibility and biodistribution.

Main Results:

  • Polystyrene nanoparticles exhibit distinct behaviors based on surface charge (positive vs. negative).
  • Surface chemistry is a key determinant of nanoparticle durability, solubility, biocompatibility, and biodistribution.
  • Polystyrene nanoparticles serve as a reliable platform for investigating bio-nano interactions.

Conclusions:

  • Polystyrene nanoparticles are excellent model systems for studying nanoparticle-biological interactions.
  • Understanding surface chemistry is crucial for predicting nanoparticle behavior in biological systems.
  • Further research is needed to fully elucidate nanoparticle hazards and optimize their biomedical applications.