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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

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Published on: October 8, 2015

Paraprotein interference with turbidimetric gentamicin assay.

Goce Dimeski¹, Kendra Bassett¹, Nigel Brown¹

¹Department of Chemical Pathology, Pathology Queensland, Princess Alexandra Hospital, Brisbane, Australia.

Biochemia Medica

|February 13, 2015

Summary

High IgM paraprotein caused interference in gentamicin, vancomycin, and valproate assays, leading to inaccurate results. Ethanol precipitation effectively resolved this protein interference, enabling accurate therapeutic drug monitoring.

Area of Science:

Clinical Chemistry
Immunology
Pharmacology

Background:

Gentamicin is a crucial antibiotic for gram-negative infections, requiring therapeutic drug monitoring due to toxicity.

Keywords:

IgM interference paraprotein turbidimetry

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No prior interference with gentamicin assays had been reported.

Patient presented with leg cellulitis and sepsis, necessitating gentamicin treatment and monitoring.