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Calcifying/ossifying synovial sarcoma: a clinicopathologic and molecular study of 5 cases
Nasir Ud Din1, Amanda Hopkins, Aisha Memon
1Department of Pathology and Microbiology, Section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan.
Indian Journal of Pathology & Microbiology
|February 13, 2015
Summary
Calcifying/ossifying synovial sarcoma (SS) is a rare variant with a favorable prognosis. This study reports on 5 cases, confirming their distinct clinicopathological features and the presence of the SYT/SSX fusion transcript, supporting a good clinical outcome.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Background:
- Synovial sarcoma (SS) is a typically aggressive soft tissue sarcoma.
- Calcifying/ossifying SS is a rare subtype with a generally favorable prognosis.
Purpose of the Study:
- To detail the clinicopathological characteristics of calcifying/ossifying SS.
- To perform molecular analysis on a series of calcifying/ossifying SS cases.
Main Methods:
- Retrospective review of 370 SS cases from 2002-2011.
- Identification and analysis of 5 cases with extensive calcification/ossification.
- Immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR) for molecular analysis.
Main Results:
- The 5 cases ranged in age from 13-44 years, with a female predominance (1.6:1).
- Histology showed extensive calcification or ossification. Immunohistochemistry revealed positive markers including EMA, CKAE1/AE3, Bcl2, S100, CK7, CD99, and vimentin.
- Molecular analysis confirmed the SYT/SSX fusion transcript in 3 cases.
Conclusions:
- Clinicopathological features of calcifying/ossifying SS were reported.
- The findings support the favorable prognosis associated with this rare SS variant.
- A slight female predominance was observed, contrasting with literature reports.
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