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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

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Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Updated: Apr 17, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
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Oritavancin diphosphate.

Dennis J Cada1, Danial E Baker2

  • 1Founder and Contributing Editor, The Formulary , Washington State University , Spokane, Washington.

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Summary
This summary is machine-generated.

The Formulary Monograph Service provides monthly drug monographs and utilization evaluations for Pharmacy & Therapeutics Committees. This service aids in informed drug selection and safe medication use for healthcare facilities.

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Area of Science:

  • Pharmacy and Therapeutics
  • Drug Information Services
  • Clinical Pharmacy

Background:

  • The Formulary Monograph Service delivers essential drug information to healthcare professionals.
  • Monographs focus on newly released or late-stage investigational drugs.
  • Targeted content supports Pharmacy & Therapeutics Committees.

Purpose of the Study:

  • To provide comprehensive drug monographs and utilization evaluations.
  • To support informed decision-making in drug formulary management.
  • To offer resources for pharmacy and nursing in-services.

Main Methods:

  • Monthly delivery of 5-6 detailed drug monographs.
  • Inclusion of 1-page summary monographs for quick reference.
  • Provision of a comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE).

Main Results:

  • Subscribers receive print and online access to monographs.
  • Customization options are available to meet facility-specific needs.
  • A monthly drug class review is now included.

Conclusions:

  • The service enhances drug information accessibility for P&T Committees.
  • It facilitates evidence-based medication use evaluations.
  • The Formulary Monograph Service is a valuable resource for formulary management and clinical practice.