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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
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Liver transplantation and autoimmune hepatitis
Tomohiro Tanaka1, Yasuhiko Sugawara2, Norihiro Kokudo2
1Organ Transplantation Service, The University of Tokyo Hospital, Tokyo, Japan;
Intractable & Rare Diseases Research
|February 13, 2015
Summary
Liver transplantation (LT) offers a viable treatment for end-stage autoimmune hepatitis (AIH). While infrequent, LT outcomes are feasible, but recurrent AIH post-transplant requires distinct management strategies.
Area of Science:
- Hepatology
- Transplant Surgery
- Immunology
Background:
- Autoimmune hepatitis (AIH) is a chronic liver disease.
- Liver transplantation (LT) is an effective treatment for end-stage liver disease.
- AIH is an infrequent indication for LT globally due to immunosuppression advances.
Purpose of the Study:
- To review the characteristics of AIH.
- To focus on indications for LT in AIH patients.
- To discuss issues arising post-LT for AIH.
Main Methods:
- Literature review of AIH and LT.
- Analysis of indications for LT in AIH.
- Discussion of post-LT complications and management.
Main Results:
- LT outcomes for AIH are feasible, with >75% patient and graft survival at 5 years.
- Recurrent and de-novo AIH post-LT can occur.
- Management of recurrent/de-novo AIH differs from allograft rejection.
Conclusions:
- LT is a viable option for select AIH patients.
- Post-LT AIH recurrence presents unique clinical challenges.
- Further research into managing AIH post-LT is warranted.
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