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Related Experiment Videos

Response to bronchodilators.

C Shim1

  • 1Pulmonary Division, Albert Einstein College of Medicine, Bronx, New York.

Clinics in Chest Medicine
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Testing bronchodilator response helps diagnose airflow obstruction and plan therapy. While beneficial for asthma, a positive response in COPD may not guarantee long-term treatment benefits.

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Bronchodilator response testing is crucial for diagnosing airflow obstruction and guiding long-term therapy.
  • Key metrics include forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and mid-expiratory flow rates (FEF25-75% or FEF50%).
  • Interpreting pulmonary function changes in COPD can be challenging due to daily variability.

Purpose of the Study:

  • To outline the established criteria for assessing bronchodilator response.
  • To discuss the agents and methods used for bronchodilator response testing.
  • To evaluate the implications of bronchodilator response in asthma versus COPD management.

Main Methods:

  • Utilizing FEV1, FVC, and FEF25-75%/FEF50% to assess reversibility of airflow obstruction.

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  • Employing beta-adrenergic agonists, theophylline, or anticholinergic agents for testing.
  • Administering two puffs of a beta-adrenergic agonist via metered-dose inhaler (MDI) as a practical laboratory method.

    • Main Results:

    • Acceptable criteria include a 15% increase in FEV1 or FVC, and a 30% increase in isovolume FEF25-75% or FEF50% above baseline.
    • Beta-adrenergic agonists are commonly used, with MDI administration being convenient.
    • Bronchodilator response is generally considered beneficial for asthma treatment.

    Conclusions:

    • Bronchodilator response testing is a standard diagnostic tool for airflow obstruction.
    • While a positive response is beneficial in asthma, its predictive value for long-term COPD treatment benefit is less reliable.
    • Careful interpretation is needed, especially in COPD patients with significant day-to-day pulmonary function variability.