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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Guidelines for severe uncontrolled asthma.

Carolina Cisneros Serrano¹, Carlos Melero Moreno², Carlos Almonacid Sánchez³

¹Servicio de Neumología, Hospital Universitario La Princesa, Madrid, España.

Archivos De Bronconeumologia

|February 14, 2015

Summary

This summary is machine-generated.

Updated guidelines address difficult-to-control asthma (DCA), defining severe uncontrolled asthma and proposing new diagnostic and treatment strategies. These advancements aim to improve patient care and management of complex asthma cases.

Keywords:

Asma grave Asma no controlada Asthma phenotype Asthma treatment Fenotipado del asma Severe asthma Tratamiento del asma Uncontrolled asthma

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Area of Science:

Pulmonology
Allergy and Immunology
Clinical Practice Guidelines

Background:

Significant advancements in understanding asthma have occurred since the last SEPAR Guidelines on Difficult-to-Control Asthma (DCA) were published 9 years ago.
Existing guidelines require review and incorporation of new evidence to reflect current knowledge in asthma management.
Recent consensus documents and clinical practice guidelines (CPG) offer updated perspectives on DCA.

Purpose of the Study:

To review and incorporate recent scientific progress into updated guidelines for difficult-to-control asthma (DCA).
To propose a revised definition and classification for severe uncontrolled asthma.
To outline a stepwise diagnostic procedure and phenotype-targeted treatment strategies for DCA, including a specific focus on childhood DCA.

Main Methods:

Systematic review and analysis of recent scientific literature and consensus documents.
Evaluation of evidence to establish recommendations for guideline updates.
Development of a revised definition and classification for DCA based on current understanding.
Proposal of a stepwise diagnostic approach and phenotype-targeted therapies.

Main Results:

A revised definition of "true difficult-to-control asthma" (severe uncontrolled asthma) is proposed, distinguishing it from "false difficult-to-control asthma."
A classification of various DCA manifestations is suggested.
A stepwise diagnostic procedure and phenotype-targeted treatment recommendations are outlined.
A dedicated section on DCA in childhood is included to guide healthcare professionals.

Conclusions:

The updated guidelines provide a refined framework for identifying and managing severe uncontrolled asthma.
The proposed strategies emphasize a systematic diagnostic process and personalized, phenotype-targeted treatments.
These revisions aim to enhance the clinical care and outcomes for patients with difficult-to-control asthma, particularly children.