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Selective solid-phase extraction of artificial chemicals from milk samples using multiple-template surface

Jing Zhang1, Yan-li Ni1, Ling-ling Wang1

  • 1Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.

Biomedical Chromatography : BMC
|February 14, 2015
PubMed
Summary

A novel polymer selectively captures drug residues like ofloxacin and 17β-estradiol. This material efficiently pre-treats complex samples for simultaneous analysis of quinolone and estrogen contaminants in food.

Keywords:
estrogenmultiple-template surface molecularly imprinted polymerquinolonesimultaneous analysissolid-phase extraction

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Area of Science:

  • Polymer Chemistry
  • Analytical Chemistry
  • Environmental Science

Background:

  • Drug residues, including ofloxacin and 17β-estradiol, are common contaminants in food.
  • Selective and efficient methods are needed for detecting multiple drug residues in complex matrices.
  • Molecularly imprinted polymers (MIPs) offer potential for selective analyte recognition.

Purpose of the Study:

  • To synthesize and characterize a novel multiple-template surface molecularly imprinted polymer (MTMIP).
  • To evaluate the MTMIP's adsorption properties and selective recognition for quinolones and estrogens.
  • To assess the MTMIP's applicability as a solid-phase extraction (SPE) material for simultaneous analysis of drug residues in milk.

Main Methods:

  • Synthesis of MTMIP using ofloxacin and 17β-estradiol as templates on PGMA/EDMA beads.
  • Investigation of adsorption properties via static adsorption experiments.
  • Evaluation of selective recognition using solid-phase extraction (SPE) and high-performance liquid chromatography (HPLC).

Main Results:

  • The MTMIP demonstrated high binding capacities for ofloxacin (9.0 mg/g) and 17β-estradiol (6.6 mg/g).
  • MTMIP exhibited significantly enhanced adsorption and selectivity towards quinolone and estrogen drug residues compared to non-imprinted polymers.
  • Successful application of MTMIP for simultaneous analysis of multiple drug residues in milk samples with recoveries ranging from 77.6% to 98.0%.

Conclusions:

  • The developed MTMIP is a promising material for selective preconcentration of multiple drug residues.
  • MTMIP serves as an effective pretreatment method for simultaneous determination of quinolones and estrogens in complex samples like milk.
  • This approach offers a valuable tool for monitoring common drug contaminants in food safety applications.