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Updated: Apr 17, 2026

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
Published on: July 28, 2023
Infectious causes of necrotizing enterocolitis
Sarah A Coggins1, James L Wynn2, Jörn-Hendrik Weitkamp2
1Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA.
Abstract:
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency among premature infants. Although a large body of research has focused on understanding its pathogenesis, the exact mechanism has not been elucidated. Of particular interest is the potential causative role of infectious culprits in the development of NEC. A variety of reports describe bacterial, viral, and fungal infections occurring in association with NEC; however, no single organism has emerged as being definitively involved in NEC pathogenesis. In this review, the authors summarize the literature on infectious causes of NEC.
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