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Published on: December 9, 2010
Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen
Anthony J Lee1, Ronald J Bosch, Scott R Evans
1Center for Biostatistics in AIDS Research, Department of Biostatistics, FXB 604B, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA, 02115, USA, alee@sdac.harvard.edu.
Abstract:
The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.
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