Related Experiment Video
Updated: Apr 17, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
Working night shifts affects surgeons' biological rhythm
Ilda Amirian1, Lærke T Andersen1, Jacob Rosenberg1
1Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730 Herlev, Denmark.
Night shifts disrupt surgeons' circadian rhythms, impacting sleep-wake cycles and well-being. This study highlights the physiological effects of night shifts on surgical residents.
Area of Science:
- Medical Research
- Chronobiology
- Surgical Residency
Background:
- Chronic sleep deprivation and night work negatively impact performance and safety.
- Understanding the effects on surgeons is crucial for patient and resident well-being.
Purpose of the Study:
- To investigate circadian rhythm and sleep-wake cycle markers in surgeons working night shifts.
- To quantify the physiological and subjective impact of night call on surgical residents.
Main Methods:
- Prospective monitoring of surgeons over 4 days (pre-call, on-call, post-call day 1 & 2).
- Measurement of urinary melatonin metabolite and salivary cortisol to assess circadian rhythm.
- Actigraphy for sleep and activity tracking, alongside subjective scales for sleepiness, fatigue, and well-being.
Main Results:
- Significant alterations in melatonin and cortisol levels were observed on call compared to pre-call.
- Increased daytime sleep duration was noted on call and post-call day 1.
- Marked deterioration in subjective measures of sleepiness, fatigue, and well-being occurred on post-call day 1.
Conclusions:
- Night shifts significantly disrupt the circadian rhythm of surgeons.
- The findings underscore the physiological toll of night call on surgical residents, affecting their health and potentially performance.
Related Concept Videos
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...

