Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Positron Range Correction with Texture Preservation Framework in PET Imaging.

ArXiv·2026
Same author

Standardized contrast-enhanced CT-based radiomics for non-invasive prediction of TTF-1 status in lung adenocarcinoma: A cross-validated single-center study.

European journal of radiology open·2026
Same author

Limitations in diagnostics and quantification of small lesions with low uptake in the clinical context of prostate <sup>18</sup>F/<sup>68</sup>Ga-PSMA PET/MRI.

EJNMMI physics·2026
Same author

Incident learning systems to improve patient safety in nuclear medicine across Europe: results of the MARLIN study.

European journal of nuclear medicine and molecular imaging·2026
Same author

Subtype-specific prognostic impact of TNIK in medulloblastoma.

Journal of neuro-oncology·2026
Same author

Host-Atom-Driven Transformation of a Honeycomb Oxide into a Dodecagonal Quasicrystal.

Physical review letters·2026

Related Experiment Video

Updated: Apr 17, 2026

Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

2.6K

MR-based attenuation correction using ultrashort-echo-time pulse sequences in dementia patients.

Jorge Cabello1, Mathias Lukas2, Stefan Förster3

  • 1Nuklearmedizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and jorge.cabello@tum.de.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|February 14, 2015
PubMed
Summary

Accurate brain PET quantification requires accounting for bone in attenuation maps. This study presents a novel MR-based method to improve attenuation correction (AC) for dementia patients, reducing errors by over 15%.

Keywords:
18F-FDG PETPET/MRUTE sequenceattenuation correctionbrain imaging

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.2K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.8K

Related Experiment Videos

Last Updated: Apr 17, 2026

Transcranial Pulse Stimulation for Alzheimer's Patients
06:08

Transcranial Pulse Stimulation for Alzheimer's Patients

Published on: April 4, 2025

2.6K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

10.2K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

20.8K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Accurate quantitative positron emission tomography (PET) reconstruction necessitates robust attenuation correction (AC).
  • Incorporating bone information into the attenuation map (μ map) is crucial for precise brain PET quantification, yet challenging with MRI.
  • Ignoring bone in AC can lead to quantitative bias in (18)F-FDG PET/MR studies, particularly impacting superficial brain structures affected in neurodegenerative dementias.

Purpose of the Study:

  • To develop and validate a fully automatic method for estimating an MR-only μ map that accurately includes bone tissue.
  • To improve the diagnostic accuracy of (18)F-FDG PET/MR in neurodegenerative dementing disorders by mitigating attenuation artifacts.

Main Methods:

  • Utilized a dual-echo ultrashort-echo-time (UTE) MR imaging sequence to generate an R2 map, from which the μ map was derived.
  • Postprocessed the R2-based μ map to estimate bone tissue distribution.
  • Compared the proposed R2-based μ map against CT-based μ maps (μ mapCT) and standard scanner-derived μ maps (μ mapDX, μ mapUTE) using data from 9 patients.

Main Results:

  • PET AC using standard Dixon-based (μ mapDX) and UTE-based (μ mapUTE) μ maps showed approximately 20% higher errors compared to CT-based μ maps.
  • The proposed R2-based μ map significantly improved PET AC, reducing quantification errors to -5.8% to 2.5% across all analyzed regions and patients.

Conclusions:

  • The novel R2-based μ map method provides significantly more accurate PET image quantification compared to existing MR-based methods.
  • This improved quantification facilitates a more reliable diagnostic workup for dementia patients undergoing (18)F-FDG PET/MR.