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Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine
P S Foster1, E Gesini, C Claudianos
1Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra A.C.T.
Lancet (London, England)
|July 15, 1989
Abstract:
The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.