Multiple lithium-dependent Brugada syndrome unmasking events in a bipolar patient
Rebecca R Crawford1, Ashlee N Higdon1, David B Casey2
1Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center New Orleans, Louisiana.
Abstract:
This case demonstrates two important points about Brugada syndrome unmasking: electrocardiograph abnormality severity may correspond to lithium levels and unmasking may occur in the therapeutic range of lithium. Also, the correlation of CACNA1C with Brugada and Bipolar suggests allelic disequilibrium, leading to a subpopulation of bipolar patients sensitive to arrhythmia.
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