Related Experiment Video

Updated: Apr 17, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

9.3K

Left ventricular ejection fraction is associated with prevalent and incident cardiovascular disease in patients with

Barbara Rantner1, Johannes Pohlhammer2, Marietta Stadler3

  • 1Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria; Department of Vascular Surgery, Medical University of Innsbruck, Innsbruck, Austria.

Atherosclerosis
|February 16, 2015
PubMed

Insights

Patients with peripheral arterial disease (PAD) have significantly lower left ventricular ejection fraction (LVEF), indicating impaired heart function. Lower LVEF predicts future cardiovascular disease and mortality in this high-risk group.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Cardiovascular Imaging

Background:

  • Impaired ventricular function is linked to poor prognosis and increased mortality from heart failure.
  • Peripheral arterial disease (PAD) patients are a high-risk group for left ventricular systolic dysfunction (LVSD).

Purpose of the Study:

  • To investigate the association between left ventricular ejection fraction (LVEF) and peripheral arterial disease (PAD).
  • To evaluate LVEF as a predictor of cardiovascular disease (CVD) and mortality in PAD patients.

Main Methods:

  • Measured LVEF in 180 male PAD patients with intermittent claudication and 226 controls from the CAVASIC Study.
  • Prospectively followed patients for a median of 7 years, analyzing associations with prevalent/incident CVD and survival rates.

Main Results:

  • LVSD (LVEF <55%) prevalence was 30% in PAD patients vs. 7% in controls (p < 0.001).
  • Lower LVEF was significantly associated with PAD (OR=1.72) and prevalent CVD (OR=1.60).
  • Impaired LVEF significantly increased risk for incident major CVD events (HR=1.56, p < 0.01).

Conclusions:

  • PAD patients exhibit significantly lower LVEF compared to controls.
  • LVEF serves as a valuable risk predictor for subsequent cardiovascular disease in high-risk PAD populations.
Abstract

Keywords:
BiomarkerCardiovascular diseaseLeft ventricular ejection fractionMortalityPeripheral arterial disease

More Related Videos

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

3.8K
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

28.2K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
715
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.5K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
628
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
592
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
626