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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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A cautionary note on using binary calls for analysis of DNA methylation

Agnieszka Prochenka1, Piotr Pokarowski2, Piotr Gasperowicz2

  • 1Institute of Computer Science, Polish Academy of Sciences, Jana Kazimierza 5, Warsaw, Poland, Department of Medical Genetics, Medical University of Warsaw, Pawińskiego 3c, Warsaw, Poland, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Banacha 2, Warsaw, Poland, Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 2, Warsaw, Poland, Central Forensic Laboratory of the Police, Aleje Ujazdowskie 7, Warsaw, Poland and Institute of Forensic Research, Westerplatte 9, Krakow, Poland Institute of Computer Science, Polish Academy of Sciences, Jana Kazimierza 5, Warsaw, Poland, Department of Medical Genetics, Medical University of Warsaw, Pawińskiego 3c, Warsaw, Poland, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Banacha 2, Warsaw, Poland, Department of Immunology, Center for Biostructure Research, Medical University of Warsaw, Banacha 2, Warsaw, Poland, Central Forensic Laboratory of the Police, Aleje Ujazdowskie 7, Warsaw, Poland and Institute of Forensic Research, Westerplatte 9, Krakow, Poland.

Bioinformatics (Oxford, England)
|February 16, 2015
PubMed
Summary

No abstract available in PubMed .

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