Related Experiment Video
Updated: Apr 17, 2026
07:41
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
9.7K
Enabling semantic interoperability in multi-centric clinical trials on breast cancer
Raul Alonso-Calvo1, David Perez-Rey1, Sergio Paraiso-Medina1
1Biomedical Informatics Group, DLSIIS & DIA, Facultad de Informática, Universidad Politécnica de Madrid, Campus de Montegancedo S/N, 28660 Boadilla del Monte, Madrid, Spain.
Computer Methods and Programs in Biomedicine
|February 17, 2015
Summary
This study introduces a standard-based solution for uniform patient data access in multi-institutional clinical trials, enhancing data integration and retrieval efficiency for research.
Area of Science:
- Biomedical Informatics
- Clinical Research Informatics
- Health Data Standards
Background:
- Post-genomic clinical trials necessitate data collection from multiple institutions, including hospitals, labs, and research facilities.
- Integrating patient data across diverse healthcare settings presents significant challenges for clinical research.
Purpose of the Study:
- To present a standard-based solution for uniform access to patient data in clinical research.
- To address the need for seamless data integration in multi-institutional post-genomic trials.
Main Methods:
- Leveraging established standards like Health Level Seven (HL7) v3 and SPARQL.
- Utilizing medical vocabularies such as Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT), Logical Observation Identifiers Names and Codes (LOINC), and HUGO Gene Nomenclature Committee (HGNC).
- Employing Semantic Web technologies for semantic normalization between HL7 data models and biomedical ontologies.
Main Results:
- Demonstrated successful semantic interoperability through various query tests.
- Achieved efficient data retrieval times, suitable for end-user tools requiring integrated data access.
- Validated the solution's performance in retrieving clinical patient data from heterogeneous sources.
Conclusions:
- The proposed solution was successfully tested within the INTEGRATE and EURECA European Union projects.
- Applications were deployed for patient screening, trial recruitment, and retrospective analysis.
- The approach enables semantically interoperable access to clinical patient data, facilitating multi-site research.
Related Concept Videos
01:16Clinical Trials
11.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
11.2K
01:11Clinical Trials: Overview
5.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K
02:56Treatment Resistent Cancers
1.5K
1.5K
02:56Treatment Resistant Cancers
3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
01:13Bioequivalence studies: Biowaivers
414
In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
414
02:49Cancer Therapies
10.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.9K