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Multiple milia formation induced by dovitinib.

Dongyun Shin¹, Jimyung Seo, Soo Min Kim

¹Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

The Journal of Dermatology

|February 17, 2015

Summary

Dovitinib, a cancer drug, can cause milia, a type of non-inflammatory skin cyst. This study reports two cases of milia formation linked to dovitinib treatment.

Keywords:

anticancer drug side-effects cutaneous side-effects dovitinib milia milium

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Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Dovitinib is a multi-target tyrosine kinase inhibitor investigated for various cancers.
Previous trials noted cutaneous adverse events in 20% of patients receiving dovitinib for renal cell carcinoma.
The specific type of skin rash associated with dovitinib has not been well-documented.

Observation:

This report details two cases of patients who developed multiple milia.
Milia are small, non-inflammatory, white or yellowish cysts on the skin.
These cases specifically highlight milia formation as a potential adverse event.

Findings:

Dovitinib treatment was associated with the development of multiple milia in two patients.
The observed milia were characterized as non-inflammatory cystic structures.
This represents the first report focusing on dovitinib-induced milia.

Implications:

Milia formation should be considered a potential cutaneous adverse event of dovitinib therapy.
Further investigation into the dermatological side effects of dovitinib is warranted.
This finding may inform clinical monitoring and patient counseling during dovitinib treatment.