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Updated: Apr 17, 2026
29:41
Bacterial Gene Expression Analysis Using Microarrays
Published on: May 28, 2007
9.4K
The UCSC Ebola Genome Portal.
Maximilian Haeussler1, Donna Karolchik1, Hiram Clawson1
1CBSE, University of California Santa Cruz, Santa Cruz, California, USA.
Plos Currents
|February 17, 2015
Summary
Researchers developed the UCSC Ebola Genome Browser to visualize Ebola virus genomic data. This tool aids in understanding the virus
Area of Science:
- Genomics
- Bioinformatics
- Virology
Background:
- The West African Ebola epidemic generated extensive genomic data.
- A need exists for integrated tools to analyze molecular sequence research.
Purpose of the Study:
- To create a specialized web tool for visualizing Ebola virus genomic data.
- To provide a centralized platform for Ebola virus research resources.
Main Methods:
- Developed the University of California Santa Cruz (UCSC) Ebola Genome Browser, adapting the existing UCSC Genome Browser.
- Integrated GenBank sequence data with nearly 30 annotation tracks.
- Created a multiple genome alignment of 102 current outbreak Ebola genomes, 56 from previous outbreaks, and 2 Marburg genomes.
- Extended the color-coding scheme to differentiate mutation types (non-synonymous, synonymous, untranslated regions).
Main Results:
- The UCSC Ebola Genome Browser visualizes Ebola virus genome sequence and associated annotations.
- Key annotations include a comprehensive multiple genome alignment and curated gene, protein, and antibody epitope data.
- Enhanced visualization distinguishes various mutation types within the Ebola virus genome.
Conclusions:
- The Ebola Genome portal provides access to the Ebola virus Genome Browser.
- The portal aggregates valuable information, including a curated collection of Ebola antibodies.
- This resource facilitates research into the Ebola virus genome and potential therapeutic targets.
