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Updated: Apr 17, 2026
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Binary DNA hairpin-based colorimetric biochip for simultaneous detection of Pb(2+) and Hg(2+) in real-world samples
Xiaoli Shi1, Xiaoyi Gao, Lingling Zhang
1Department of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. liyc@bnu.edu.cn.
Abstract:
A microarray-format colorimetric biochip was constructed on plastic using two specially-designed DNA hairpin strands as binary probes and a binding-induced conformational switching strategy as the signal generation protocol. Coupled with single- or dual-color staining, we were able to simultaneously detect and quantitate the trace amounts of Pb(2+) and Hg(2+) in various real-world samples.
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