Related Experiment Video
Updated: Apr 17, 2026

Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge
Published on: January 20, 2023
Ocular pressure waveform reflects ventricular bigeminy and aortic insufficiency
Jean B Kassem, Steven E Katz, Ashraf M Mahmoud
1Department of Ophthalmology and Visual Science, The Ohio State University Medical Center, Columbus, Ohio; Department of Biomedical Engineering, The Ohio State University Medical Center, Columbus, Ohio, USA.
An irregular ocular pulse amplitude (OPA) in intraocular pressure (IOP) indicated a serious heart condition. Correcting aortic valve insufficiency resolved the abnormal OPA, highlighting the waveform
Area of Science:
- Ophthalmology
- Cardiology
- Medical Diagnostics
Background:
- Ocular pulse amplitude (OPA) measures the variation in intraocular pressure (IOP) during the cardiac cycle.
- Elevated OPA and irregular IOP waveforms can indicate underlying cardiovascular issues.
- Normal OPA values typically range from 1 to 4 mmHg.
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