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Updated: Apr 17, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Coprisamides A and B, new branched cyclic peptides from a gut bacterium of the dung beetle Copris tripartitus
Soohyun Um1, So Hyun Park, Jihye Kim
1Natural Products Research Institute, College of Pharmacy, Seoul National University , Seoul, 151-742, Republic of Korea.
Abstract:
Coprisamides A and B (1 and 2) were isolated from a bacterium in the gut of the dung beetle Copris tripartitus. Spectroscopic analysis revealed that the planar structures of 1 and 2 are novel cyclic heptapeptides bearing unusual units, such as β-methylaspartic acid and 2,3-diaminopropanoic acid branched to valine and 2-heptatrienyl cinnamic acid. Absolute configurations were established by chemical derivatization and chiroptical spectroscopy. The coprisamides displayed significant activity for induction of quinone reductase.
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