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Updated: Jul 15, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Watching polymers grow: real time monitoring of polymerizations via an on-line ESI-MS/microreactor coupling
Joris J Haven1, Joke Vandenbergh1, Tanja Junkers1
1Polymer Reaction Design Group, Institute for Materials Research (IMO) Universiteit Hasselt, Agoralaan D, B-3590 Diepenbeek, Belgium. tanja.junkers@uhasselt.be.
Abstract:
A technique for the continuous on-line monitoring of polymerization processes by electrospray ionization mass spectrometry (ESI-MS) is presented via coupling with a commercial microreactor system. The potential is demonstrated by monitoring polymerizations in real time under synthesis conditions. Furthermore, a single acrylate monomer insertion into a oligo-RAFT agent, as used in the synthesis of monodisperse sequence controlled materials, was optimized by on-line screening of reaction conditions.
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