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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Does everyone develop covert cancer?

Mel Greaves1

  • 1Centre for Evolution and Cancer, The Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. mel.greaves@icr.ac.uk

Nature Reviews. Cancer
|February 18, 2015
PubMed
Summary
This summary is machine-generated.

Most individuals will develop overt cancer if they live long enough. Emerging evidence suggests that all individuals may develop covert cancer, indicating a high prevalence of undetected cancer across the population.

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Area of Science:

  • Oncology
  • Cancer Biology

Background:

  • Overt cancer affects approximately one-third of individuals during their lifetime.
  • Subclinical or covert cancer may be far more prevalent than clinically diagnosed cases.

Purpose of the Study:

  • To highlight the potential high incidence of covert cancer.
  • To emphasize the need for further research into early cancer detection and prevention.

Main Methods:

  • Review of existing epidemiological data on cancer incidence.
  • Analysis of emerging evidence on subclinical cancer development.

Main Results:

  • Confirms a significant lifetime risk of overt cancer.
  • Presents a strong argument for the universal development of covert cancer.

Conclusions:

  • The lifetime risk of developing clinically detectable cancer is substantial.
  • Covert cancer may be a universal phenomenon, necessitating a paradigm shift in cancer screening and management strategies.