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Updated: Apr 17, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Diverse presentations of acral melanoma
Robyn P M Saw1, Annette H Chakera, Jonathan R Stretch
1MBMS, FRACS, Surgeon, Melanoma Institute Australia, Royal Prince Alfred Hospital, Division of Surgery, The University of Sydney, NSW.
Background:
Acral melanoma (AM) is an uncommon melanoma subtype occurring on the palms, soles and nail apparatus. It often lacks the typical features of primary melanoma resulting in delayed diagnosis.
Objective:
This article aims to raise awareness of AM and promote a high index of clinical suspicion to enable early diagnosis and improve outcomes for patients with AM.
Discussion:
The diagnosis of AM is often delayed because its presentation mimics other benign conditions such as fungal infections and ulcers. When lesions that were thought to be benign fail to respond to appropriate therapies, biopsy is critically important to exclude AM or other malignant pathology. Clinician awareness of the diversity of AM presentations, maintaining AM as part of their differential diagnosis and facilitating early biopsy are essential for early diagnosis and improving outcomes in patients with AM.
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