Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surface EEG to Identify Cognitive Motor Dissociation After Acute Brain Injury.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·2026

Same author

Sanjay Pandey, MBBS, MD, DNB, DM, FIAN, and Aasef Shaikh, MD, PhD.

Seminars in neurology·2026

Same author

A Modified Delphi Consensus-Based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination.

Critical care medicine·2026

Same author

Integrating Brain Imaging Volumetrics and Quantitative Pupillometry for Predicting Neurologic Deterioration after Large Hemispheric Stroke.

Neurocritical care·2026

Same author

Connectome disruptions after hypoxic-ischaemic injury associate with consciousness disorder severity.

Brain communications·2026

Same author

Joseph Schindler, MD, and Charles Matouk, MD.

Seminars in neurology·2026

Same journal

Cardiogenic shock - toward phenotype-directed, precision management.

Current opinion in critical care·2026

Same journal

The future of critical care nutrition: from calorie counting to precision personalized metabolism therapy.

Current opinion in critical care·2026

Same journal

Editorial introduction.

Current opinion in critical care·2026

Same journal

Generative artificial intelligence for outcome prediction in critical care: the future is now?

Current opinion in critical care·2026

Same journal

Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy.

Current opinion in critical care·2026

Same journal

Multinational collaborations in critical care research: feasible and useful?

Current opinion in critical care·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 17, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

Why is diagnosing brain death so confusing?

Shivani Ghoshal¹, David M Greer

¹Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.

Current Opinion in Critical Care

|February 18, 2015

Summary

This summary is machine-generated.

Variations in brain death determination guidelines cause confusion. Standardizing physician training and hospital protocols can improve consistency in diagnosing brain death.

More Related Videos

Study of Experimental Organ Donation Models for Lung Transplantation

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Related Experiment Videos

Last Updated: Apr 17, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

Study of Experimental Organ Donation Models for Lung Transplantation

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Neurology
Medical Ethics
Clinical Practice Guidelines

Background:

Physician guidelines for brain death determination exhibit significant variability.
Public and medical confusion surrounding brain death determination persists, as exemplified by high-profile cases.

Purpose of the Study:

To review and identify common sources of variability in the process of brain death determination.
To highlight areas for improvement in clinical practice and reduce medical ambiguity.

Main Methods:

Analysis of four key studies examining variations in brain death determination practices.
Categorization of variability sources into pre-declaration, during-declaration, and post-declaration phases.

Main Results:

Key areas for improvement include examiner training, patient qualification assessment, apnea testing protocols, and the judicious use of ancillary tests.
Inconsistent application of established practice parameters contributes to diagnostic variability.

Conclusions:

Standardized physician training and certification are crucial for uniform brain death determination.
Development and implementation of national standards and hospital-specific protocols can mitigate variability and enhance diagnostic accuracy.