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Updated: Apr 17, 2026

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013
Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis
Hideki Izumi1, Kenichi Hirabayashi, Naoya Nakamura
1Department of Surgery, Tokai University School of Medicine, Kanagawa, Japan, deehii@is.icc.u-tokai.ac.jp.
Purpose:
Nectins are cell adhesion molecules that regulate the formation of adherens junctions and are linked with E-cadherin-based cell-cell adherens junctions. In pancreatic cancer, the expression of E-cadherin and nectins is considered to be related to metastasis, invasion and prognosis.
Methods:
We evaluated the distribution of cells that were positive for nectin subtypes and E-cadherin using immunohistochemistry in specimens of human pancreatic adenocarcinoma, and correlated these results with the clinicopathological features and patient outcomes.
Results:
The immunohistochemical distribution of nectin-1 and E-cadherin showed a good correlation (r = 0.523, p < 0.01). Tumors over 4 cm in diameter had more intense staining for nectin-4 than smaller tumors (p = 0.035). Nectin-2 expression correlated with a poorer histological grade (p = 0.04). The cases that showed diffuse nectin-3 expression had a better prognosis than those with negative expression (p = 0.018).
Conclusion:
Our results showed that the expression of nectin-3 in pancreatic cancer can be a prognostic factor.
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