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A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
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APTEC: aptamer-tethered enzyme capture as a novel rapid diagnostic test for malaria
Roderick M Dirkzwager1, Andrew B Kinghorn, Jack S Richards
1Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong S.A.R.. jatanner@hku.hk.
Chemical Communications (Cambridge, England)
|February 19, 2015
Abstract:
We report the rapid diagnosis of malaria by aptamer-tethered enzyme capture (APTEC) whereby an aptamer captures biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) then activity is measured colorimetrically. The robust test was sensitive (limit of detection = 4.9 ng mL(-1)) and could reliably diagnose malaria in clinical blood samples.
