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Medications for weight loss.

John P Mordes1, Chao Liu, Shuhang Xu

  • 1aDepartment of Medicine/Endocrinology, University of Massachusetts Medical School, Worcester, Massachusetts, USA bEndocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing, China.

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 19, 2015
PubMed
Summary
This summary is machine-generated.

New Western and traditional Chinese medications offer effective weight loss options. While newer Western drugs show promise with potential side effects, Chinese herbal medicines may provide a safer alternative with limited data, especially for those at risk of type 2 diabetes mellitus (T2DM).

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Area of Science:

  • Pharmacology and Therapeutics
  • Metabolic Disorders
  • Global Health

Background:

  • Rising global prevalence of overweight, obesity, and associated comorbidities necessitates urgent development of effective interventions.
  • Existing lifestyle interventions show limited long-term durability for weight management.
  • Bariatric surgery is effective but invasive, with variable long-term durability.

Purpose of the Study:

  • To review the pharmacology, benefits, and risks of Western and Chinese medications for weight loss.
  • To assess the efficacy and safety of novel pharmaceutical agents and traditional Chinese medicines.
  • To guide judicious use of weight loss medications in conjunction with lifestyle modifications.

Main Methods:

  • Review of pharmacological data, clinical trial results, and safety profiles of weight loss medications.
  • Comparative analysis of newer Western pharmaceuticals and traditional Chinese medications.
  • Evaluation of evidence for efficacy and tolerability in diverse patient populations.

Main Results:

  • Newer Western medications (lorcaserin, phentermine/topiramate, naltrexone/bupropion, liraglutide) demonstrate increased efficacy and potentially improved safety over older agents, but possess notable side effects.
  • Traditional Chinese medications show comparable efficacy to older Western drugs with a favorable side-effect profile, though supporting data are limited.
  • Bariatric surgery offers significant weight loss and type 2 diabetes mellitus (T2DM) reversal but is invasive.

Conclusions:

  • Judicious use of novel Western and traditional Chinese medications, alongside lifestyle changes, is justified for appropriate patients, particularly those with or at high risk for T2DM.
  • The role of these medications may be especially relevant in Asian populations where T2DM occurs at lower BMI.
  • Further research is needed to fully elucidate the long-term efficacy and safety of Chinese herbal medicines for weight management.