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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Myocardial viability assessment: poor correlation between electromechanical cardiac mapping and positron emission

P A van der Vleuten, E S Tan, R A Tio

    Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
    |February 20, 2015
    PubMed

    Insights

    Electromechanical mapping (EMM) for myocardial viability assessment in severe coronary artery disease did not correlate with positron emission tomography (PET). EMM is not a substitute for nuclear imaging despite its potential for online assessment.

    Area of Science:

    • Cardiology
    • Medical Imaging
    • Biomedical Engineering

    Background:

    • A novel intracardial electromechanical mapping (EMM) system allows for online myocardial viability assessment in catheterization labs.
    • Limited studies have validated this promising technique for clinical use.

    Purpose of the Study:

    • To evaluate the correlation between myocardial viability assessed by electromechanical cardiac mapping (EMM) and positron emission tomography (PET) in patients with severe coronary artery disease.
    • To compare EMM with PET, the established gold standard for myocardial viability assessment.

    Main Methods:

    • Systematic scanning of 34 patients with severe coronary artery disease undergoing both EMM and PET.
    • EMM analysis included linear local shortening and unipolar voltage measurements.
    • PET analysis involved dipyridamole stress and fluoro-deoxy-d-glucose (FDG) uptake, with data converted to nine-segment bull's-eye maps.

    Main Results:

    • Analysis included 253 EMM segments with sufficient contact points.
    • Unipolar voltage showed a trend towards lower values in infarcted segments.
    • Linear local shortening demonstrated no significant correlation with myocardial viability.

    Conclusions:

    • Myocardial viability assessment using EMM did not correspond with PET findings in this cohort.
    • While online myocardial assessment offers advantages, quantitative EMM measurements are not a definitive replacement for nuclear imaging techniques like PET.
    Abstract

    Keywords:
    electromechanical cardiac mappingpositron emission tomographyviability assessment

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