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Updated: Apr 17, 2026
Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
Published on: March 13, 2015
What is the right blood hematocrit preparation procedure for standards and quality control samples for dried blood
Remco A Koster1, Jan-Willem C Alffenaar, Rixt Botma
1Laboratory for Clinical & Forensic Toxicology & Drugs Analysis, Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Abstract:
Remco Koster is a research analyst and PhD candidate at the University Medical Center Groningen and University of Groningen. He has been working in the field of bioanalysis for over 13 years, where he has developed numerous analytical methods using LC-MS/MS. His main research focus is the influence of various matrices on the development and performance of analytical methods using LC-MS/MS. The development of high-speed extraction and analysis methods for drugs and drugs of abuse in human matrices like blood, plasma, hair, saliva and dried blood spots often leads to improved procedures for preparation of standards and quality control samples, sample handling and validation. Two hematocrit preparation procedures for standards and quality control samples were evaluated in order to improve the quality of procedures for dried blood spot validation and analysis.
