Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Proofreading01:43

Proofreading

62.7K
Overview
62.7K
Proofreading01:31

Proofreading

10.0K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
10.0K
Proofreading01:43

Proofreading

21.2K
21.2K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

10.5K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
10.5K
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

1.2K
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
1.2K
Accuracy and Errors in Hypothesis Testing01:13

Accuracy and Errors in Hypothesis Testing

709
Hypothesis testing is a fundamental statistical tool that begins with the assumption that the null hypothesis H0 is true. During this process, two types of errors can occur: Type I and Type II. A Type I error refers to the incorrect rejection of a true null hypothesis, while a Type II error involves the failure to reject a false null hypothesis.
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5%...
709

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Reference values for urinary 2-phenyl-2-propanol as a biomarker of cumene exposure in a non-occupationally exposed population determined by GC-MS.

Bioanalysisยท2026
Same journal

A UHPLC-MS/MS method for the simultaneous quantification of BTK inhibitors and their active metabolite in human plasma and cerebrospinal fluid.

Bioanalysisยท2026
Same journal

Drawing a line in the sand: impact of analytical choices on anti-drug antibody cut-points and testing outcomes.

Bioanalysisยท2026
Same journal

Quantification of HSK21542 in rat plasma and tissues by LC-MS/MS: an application to pharmacokinetics and tissue distribution study.

Bioanalysisยท2026
Same journal

Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults.

Bioanalysisยท2026
Same journal

A simple, sensitive microsample LC-MS assay for quercetin and isorhamnetin in mouse and human plasma: application to EMIQ treatment in myotonic dystrophy type 1.

Bioanalysisยท2026

Related Experiment Video

Updated: Apr 17, 2026

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
05:46

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

Published on: September 20, 2024

889

Corrigendum

    Bioanalysis
    |February 21, 2015
    PubMed
    Summary

    A missed reference in a bioanalysis white paper is now included. This addition clarifies the lack of consensus on defining hyperlipidemic plasma in bioanalytical method validation.

    Area of Science:

    • Bioanalytical Chemistry
    • Pharmacokinetics
    • Drug Development

    Context:

    • A white paper by the European Bioanalysis Forum addressed challenges in bioanalysis, specifically concerning hemolyzed and hyperlipidemic matrices.
    • The original publication lacked a crucial reference, leading to potential ambiguity in the discussion of hyperlipidemic plasma.
    • The absence of a standardized hyperlipidemic matrix contributes to the lack of consensus in the bioanalytical field.

    Purpose:

    • To correct an omission in a previously published white paper.
    • To provide readers with complete and accurate information regarding hyperlipidemic plasma in bioanalytical method validation.
    • To ensure the scientific rigor and clarity of recommendations concerning problematic biological matrices.

    Summary:

    More Related Videos

    Transcutaneous Microcirculatory Imaging in Preterm Neonates
    06:27

    Transcutaneous Microcirculatory Imaging in Preterm Neonates

    Published on: December 31, 2015

    8.6K
    High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
    08:18

    High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon

    Published on: June 16, 2020

    8.1K

    Related Experiment Videos

    Last Updated: Apr 17, 2026

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
    05:46

    Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity

    Published on: September 20, 2024

    889
    Transcutaneous Microcirculatory Imaging in Preterm Neonates
    06:27

    Transcutaneous Microcirculatory Imaging in Preterm Neonates

    Published on: December 31, 2015

    8.6K
    High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon
    08:18

    High-Accuracy Correction of 3D Chromatic Shifts in the Age of Super-Resolution Biological Imaging Using Chromagnon

    Published on: June 16, 2020

    8.1K
  • A reference [24] by Mayrand-Provencher et al. (2014) has been added to the European Bioanalysis Forum's white paper on handling hemolyzed and hyperlipidemic matrices.
  • The reference is inserted on page 3116, supporting the statement that there is no established consensus on defining hyperlipidemic plasma due to the lack of standardized matrices.
  • This correction aims to enhance the accuracy and completeness of the bioanalytical recommendations provided in the paper.
  • Impact:

    • Ensures readers have access to all relevant literature for understanding hyperlipidemic plasma in bioanalysis.
    • Supports the scientific community by providing a more complete reference for method validation challenges.
    • Minimizes confusion and enhances the reliability of bioanalytical data generated from lipemic samples.