Another dimension to the importance of the extracellular matrix in fibrosis

The importance of the extracellular matrix (ECM) in fibrosis has been recognized for a long time, not only because ECM's increased stiffness hampers tissue function, but also because the ECM provides the mechanical tension that maintains resident cells' synthetic phenotype. A study by Parker and colleagues (Journal of Clinical Investigation 124, 1622-1635, 2014) compared the transcriptome of fibroblasts cultured on decellularized ECM from healthy vs idiopathic pulmonary fibrosis (IPF) human lungs, and revealed that the IPF matrix exerts a positive feedback loop that increases the translation of ECM genes that are enriched in the IPF ECM proteome. This study suggests that the ECM composition, in addition to ECM stiffness or the phenotype of its resident cells, might be an important factor in maintaining a fibrotic state. Targeting this feedback loop might be an efficient therapeutic strategy for IPF.