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Updated: Apr 17, 2026
An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke
Published on: March 11, 2018
Early Blood Brain Barrier Changes in Acute Ischemic Stroke: A Sequential MRI Study.
Marc Giraud1, Tae-Hee Cho2, Norbert Nighoghossian2
1Department of Neuroradiology, Université Lyon 1, CREATIS, CNRS UMR 5220-INSERM U1044, INSA-Lyon, Hospices Civils de Lyon, Lyon, France.
Blood-brain barrier (BBB) changes are rare in the first 3 hours of ischemic stroke. Delayed BBB alterations, observed later, are linked to FLAIR MRI findings, suggesting vasogenic edema.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Ischemic stroke involves disruption of the blood-brain barrier (BBB).
- Understanding early BBB changes is crucial for acute stroke management.
Purpose of the Study:
- To identify magnetic resonance imaging (MRI) factors associated with BBB changes.
- To investigate BBB status in the acute phase of ischemic stroke.
Main Methods:
- Analysis of BBB changes using contrast enhancement on T1-weighted MRI.
- Assessment of Tmax, cerebral blood volume (CBV), and DWI lesion volume.
- Logistic regression analyses to identify associated clinical and MRI factors.
Main Results:
- BBB changes were infrequent on baseline MRI (3%).
- BBB disruption was observed in 43% of patients within 3 hours (H3-MRI).
- Delayed BBB alteration on H3-MRI strongly correlated with FLAIR MRI positivity (83%).
Conclusions:
- Blood-brain barrier changes are uncommon in the initial 3 hours post-stroke.
- Delayed BBB alteration is primarily associated with FLAIR positivity, indicating vasogenic edema.
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