An anodic aromatic C,C cross-coupling reaction using parallel laminar flow mode in a flow microreactor.

Area of Science:

• Organic Chemistry
• Electrochemistry
• Chemical Engineering

Background:

• Aromatic C,C cross-coupling reactions are fundamental in organic synthesis.
• Traditional batch methods often suffer from low yields and poor scalability.
• Electrochemical methods offer a sustainable alternative but require efficient reactor designs.

Purpose of the Study:

• To demonstrate an efficient anodic aromatic C,C cross-coupling reaction.
• To investigate the use of parallel laminar flow in a microreactor for this transformation.
• To compare the efficiency with conventional batch methods.

Main Methods:

• Utilized a two-inlet flow microreactor operating in parallel laminar flow mode.
• Performed anodic aromatic C,C cross-coupling reactions under flow conditions.
• Analyzed product yields and compared them to batch reactions.

Main Results:

• Successfully demonstrated an efficient anodic aromatic C,C cross-coupling reaction.
• Achieved higher current yields in flow-through operations compared to batch cells.
• The reaction proceeded effectively even in single flow-through operations.

Conclusions:

• Flow microreactors enable efficient anodic aromatic C,C cross-coupling.
• Parallel laminar flow enhances reaction performance and yield.
• This method presents a scalable and high-yielding alternative to batch processes.