Review on molecular and chemopreventive potential of nimbolide in cancer

Area of Science:

• Phytochemistry
• Molecular Biology
• Oncology

Background:

• Cancer remains a significant global health challenge with incompletely understood molecular mechanisms.
• Current allopathic cancer therapies can be costly, induce side effects, and potentially disrupt gene function.
• There is a need for non-toxic, effective, and affordable cancer treatment modalities.

Purpose of the Study:

• To review the molecular targets underlying the anticancer activity of nimbolide.
• To highlight nimbolide's potential as a natural therapeutic agent against cancer progression.
• To consolidate current knowledge on nimbolide's mechanisms of action.

Main Methods:

• Literature review of studies on nimbolide and its effects on cancer cells.
• Analysis of research focusing on nimbolide's impact on apoptosis and cell cycle.
• Examination of studies investigating nimbolide's inhibition of cancer-related signaling pathways.

Main Results:

• Nimbolide, a neem-derived limnoid, demonstrates significant anticancer properties.
• Nimbolide has been shown to inhibit cancer cell proliferation and metastasis.
• Key mechanisms include the induction of apoptosis and cell cycle arrest.

Conclusions:

• Nimbolide exhibits potent anticancer effects through multiple molecular targets.
• Its ability to induce apoptosis and cell cycle arrest makes it a promising candidate for cancer therapy.
• Nimbolide represents a potential safe, effective, and affordable natural remedy for controlling cancer progression.