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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Diffuse Large B-cell Lymphoma Arising from Chronic Tuberculous Empyema.

Ju Sik Yun1, Seung Ku Kang1, Jo Heon Kim2

  • 1Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hwasun Hospital, Chonnam National University School of Medicine.

The Korean Journal of Thoracic and Cardiovascular Surgery
|February 24, 2015
PubMed
Summary

Pyothorax-associated lymphoma is a rare B-cell non-Hodgkin's lymphoma linked to chronic inflammation from tuberculosis. This case highlights diffuse large B-cell lymphoma in a patient with a 30-year history of tuberculous empyema.

Keywords:
EmpyemaLungPyothorax-associated lymphoma

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Area of Science:

  • Oncology
  • Pathology
  • Infectious Diseases

Background:

  • Pyothorax-associated lymphoma (PAL) is a rare non-Hodgkin's lymphoma.
  • PAL predominantly affects patients with a history of tuberculous pleuritis or induced pneumothorax.
  • It is characterized by a B-cell phenotype and strong association with Epstein-Barr virus.

Observation:

  • A case of PAL is presented in a patient with a 30-year history of chronic tuberculous empyema.
  • The patient underwent decortication for presumed chronic empyema with fistula.
  • Histopathological examination revealed diffuse large B-cell lymphoma associated with chronic inflammation.

Findings:

  • The diagnosis confirmed pyothorax-associated lymphoma.
  • The lymphoma was of the diffuse large B-cell type.
  • Chronic inflammation from tuberculous empyema was a significant contributing factor.

Implications:

  • This case expands the understanding of PAL in Western populations.
  • Highlights the importance of considering PAL in patients with chronic empyema and B-cell lymphoma.
  • Emphasizes the link between chronic inflammation, Epstein-Barr virus, and lymphoma development.