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The effectiveness of pregabalin for post-tonsillectomy pain control: a randomized controlled trial
Soo Seog Park1, Dong-Hyun Kim2, In-Chul Nam2
1Department of Anesthesiology and Pain Medicine, College of medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Plos One
|February 24, 2015
Summary
Premedication with pregabalin significantly reduced fentanyl consumption after tonsillectomy compared to diazepam. This effective pain management strategy for tonsillectomy patients did not increase adverse effects.
Area of Science:
- Anesthesiology and Pain Management
- Pharmacology
- Surgical Outcomes
Background:
- Postoperative pain is a significant challenge following tonsillectomy.
- Current analgesic options offer variable patient relief.
Purpose of the Study:
- To assess the efficacy of pregabalin premedication versus placebo (diazepam) for postoperative pain control after tonsillectomy.
- To compare patient-controlled fentanyl use and other pain-related outcomes.
Main Methods:
- A randomized controlled trial involving 48 adult patients undergoing tonsillectomy.
- Patients received either 300 mg oral pregabalin or 4 mg oral diazepam preoperatively.
- Pain management included patient-controlled fentanyl, acetaminophen, and ketorolac as needed.
Main Results:
- Pregabalin group showed a statistically significant reduction in total fentanyl consumption (P < 0.001).
- No significant differences were observed in ketorolac use, pain scores, satisfaction, or adverse events (drowsiness, nausea, etc.) between groups.
Conclusions:
- Preoperative administration of 300 mg pregabalin effectively reduces opioid requirements after tonsillectomy.
- Pregabalin offers a favorable safety profile for pain management in this surgical context.
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