[Study of electrokinetic potential of drug micro-carriers prepared from resorbable polymers bioplastotan]

The study investigates electrokinetic potential of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ζ-potential of microparticles. prepared from emulsion by solvent evaporation method was -20 mV; the ζ-potential of microparticles prepared by spray drying was reduced to -95 mV. The value of ζ-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading.